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This indicates that the ability of MCFAs to be oxidized independently of carnitine is tissue-specific

Thats one reason why carnitine has become an effective supplement for its combined benefits in combating exercise-related fatigue and metabolising body fat

For instance, the mitochondrial shuttle-system allows the transport of fatty acids, as acylcarnitines, from the cytosol into the mitochondrial matrix where these nutrients are oxidized for ATP production

A third meta-analysis of 16 trials suggested that supplementation with (acyl)-L-carnitine may reduce fasting blood glucose and glycated hemoglobin concentrations, but not resistance to insulin (45)